Antiproton Radiotherapy Experiments at CERN

In this moment we have a week of antiproton beam at CERN for radiobiology and dosimetry experiments. The main experiment is to measure the relative biological effectiveness (RBE) of antiprotons. As an endpoint we use clonogenic survival of V79 Chinese hamster cells (in vitro).

What makes this experiment so complicated, is :

• we only have narrow beam geometry available at CERN
• antiprotons are rare, we only get app. 1 Gy / hour
• beam is highly pulsed, i.e. a 500 nanosecond spill every 90 seconds.

Therefore, we invest a lot of effort in performing precise dosimetry with multiple redundant systems. This is a long story, which I will tell more about another time. Here, let me just show a few pictures...

The antiproton beam line with a water phantom for dosimetry.

The entire experiment is located in an experimental zone at the antiproton decelerator (AD) at CERN. We share our zone with the AEgIS people, who want to find out if antiprotons fly up or down in the gravitational field of the earth. :)

Franz-Joachim Kaiser messing with the water phantom. Behind him the AEgIS beam line.

Three ionization chambers (ICs) are visible here, from the left to the right: a custom made "Advanced Roos" chamber, a Markus chamber and the MicroLion liquid ionization chamber. All by PTW.

Gafchromic EBT film irradiated with antiprotons. Beam spot is about 1 cm FWHM. The narrow beam geometry makes us very vulnerable to positioning errors...

... and therefore we also monitor the beam from spill to spill with a Mimotera detector.

We are usually 2-4 people on a shift. Tonight I will do the night shift with Franz-Joachim (to the left). Stefan will leave soon. Usually, I would do night shifts with Roy Keyes, but he couldn't be here this year.

I build this little box for the experiment: it interfaces the antiproton decelerator with the printer port of our data acquisition computer. No need for expensive IO cards or fancy LabView. Basically it is just some TTL logic and optocouplers. On the server side, a daemon listens to the parallel port if a new spill of antiprotons is coming in.

Once triggered, the server takes care to read out all data systems, such as beam current transformers, ionization chamber and scintillators.

Client programs, here running on the laptop to the left, can connect to the server, and change various settings of the readout procedure.

Again, this is home-brew. Earlier, the data acquisition was some libncurses based stuff, this year is the first time we had a traditional GUI for the client and a clear client/server separation. I wrote the client in C++/QT4 and compiled it for linux and win32. Stefan did a package for mac. Server is pure C, linux only. Sometimes, I think the most valuable course I had when I was a student at our Physics department in Aarhus, was a C-programming course.  (And that course was only offered once! What a shame!)

Fiona from the Belfast QUB group is in charge of the film scans, and making sure there are enough sweets for all of us.

Entire experimental zone in the AD hall, seen from above, where our non-existant counting hut would be..

A bit off topic, but just over our heads, there is a positron beam line, which delivers the positrons to the anti-hydrogen "bottle" of ATRAP. Positrons go from the right side to the left.

Me, checking up on things... :-) I think this is the 8th or 9th time I am working at the ACE experiment.

Alanine is one of the most reliable solid state dosimeters for such exotic beams such as antiprotons. Here a stack of pellets is prepared for irradiation.

Once the pellets have been irradiated with antiprotons, they are shipped for read out to our collaborators at the National Physical Laboratory (NPL) in Teddington, UK.. (The NPL serves also as a primary standard lab for radiation quantities.)

Alright then.. :/

Recursively posting this blog entry.

More pictures here.

How to Produce Antiprotons

Both Roy and I work on the AD-4/ACE project at CERN where we investigate antiprotons as candidate particles for use in cancer therapy. We have about one week of beam time every year where we conduct radiobiological and dosimetric experiments at the beam line in a very interdisciplinary team consisting of physicists, radiobiologists and radiation oncologists from more than 10 universities and university hospitals.

CERN is the only place in the world, where we have a antiproton beam at sufficiently *low* energy, that is, around 100 MeV which corresponds to a range of ~10 cm in water. The LHC is not involved in the production at all. In fact, for antiproton production only a relatively small amount of the CERN complex is used. However, the production is still very cumbersome. First a high energy proton beam must be made. This happens at the Proton Synchrotron (PS), the old workhorse of CERN. It was inaugurated by our great Dane Niels Bohr in 1959.
The proton beam is accelerated up to 26 GeV, and then dumped into a target followed by a so-called magnetic horn.

Antiproton production target.

Basically, it is an air cooled iridium target. When the beam is dumped, two protons are converted into three protons and an antiproton. During the dump a powerful current is sent along the beam axis, which generates a magnetic field, keeping as many antiprotons as possible on axis. Immediately after the target there is a “lithium lens” (a Russian invention), which tries to capture even more of the very precious antiprotons. The created antiprotons have a very high energy of several GeV and are then captured by the Antiproton Decelerator (AD). It then takes more than 80 seconds for the beam to slow down. The deceleration is actually not the time consuming issue, but rather shaping the beam, making it small and narrow, so antiprotons are not lost during the deceleration process.
This is realized using stochastic cooling. Along with electron cooling (which was invented by G.I. Budker, and is widely applied), this will remove energy from the transverse movements of the antiprotons, thereby reducing the emittance of the beam.

Yesterday (while following Dag Rune Olsens twitter account) I learned that Simon van der Meer, inventor of stochastic cooling - and winner of the Nobel Prize, died on 4 March 2011.
From our last antiproton run at CERN I have a large amount of video material of technicians working at the AD, which also demonstrates antiproton production and stochastic cooling of the resulting beam. Check out the excerpt below:


And yes, of all those computers, only one of them was running windows. :)

At 1:49 you can see the AD hall. The antiproton decelerater is under that ring of concrete. Those large coils at the far end, which can be seen at 1:54, are delay coax cables which “short circuit” the AD ring across the middle.
At 2:00 you see the bullseye of the production target and at 2:20 the 26 GeV proton beam hits the target as the antiprotons are made. These are slowed down, and the oscilloscope shows how emittance is reduced by stochastic cooling. The beam is then stepwise ramped down to 126 MeV, and cooled in between those steps. Finally the 126 MeV antiproton beam is extracted.
(I plan to produce more videos about the AD-4/ACE experiments, but currently kdenlive crashes frequently and corrupts my project files. It took me almost one entire day to edit those 4 min of video.)

Here is another video which shows the construction of the antiproton production target and the collector. The white cylindrical object behind the target is the lithium lens.


http://cdsweb.cern.ch/record/1063081

This is one of the “hottest” sites at CERN. Things are designed to require minimal human intervention. Here is a very old video of how a faulty magnet had to replaced near the production target. People have to plan each step in advance before they enter the zone.

http://cdsweb.cern.ch/record/1171261